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Literature summary extracted from
- Calpain 10 is required for cell viability and is decreased in the aging kidney (2009), Am. J. Physiol. Renal Physiol., 296, F478-F486.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.22.B30 | mitochondrion | - |
Mus musculus | 5739 | - |
| 3.4.22.B30 | mitochondrion | mitochondrial calpain 10 is required for cell viability | Homo sapiens | 5739 | - |
| 3.4.22.B30 | mitochondrion | mitochondrial calpain 10 is required for cell viability | Rattus norvegicus | 5739 | - |
| 3.4.22.52 | membrane | - |
Mus musculus | 16020 | - |
| 3.4.22.52 | membrane | - |
Homo sapiens | 16020 | - |
| 3.4.22.52 | membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.B30 | additional information | Homo sapiens | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? |  |
| 3.4.22.B30 | additional information | Rattus norvegicus | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? | |
| 3.4.22.B30 | additional information | Mus musculus | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.B30 | Homo sapiens | - |
- |
- |
| 3.4.22.B30 | Mus musculus | - |
- |
- |
| 3.4.22.B30 | Rattus norvegicus | - |
Fischer 344 | - |
| 3.4.22.52 | Homo sapiens | - |
- |
- |
| 3.4.22.52 | Mus musculus | - |
- |
- |
| 3.4.22.52 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.B30 | kidney | activity decreases in aging mouse kidney tissue | Mus musculus | - |
| 3.4.22.B30 | kidney | calpain 10 protein and mRNA levels decrease linearly in human kidney samples with age | Homo sapiens | - |
| 3.4.22.B30 | kidney | calpain 10 protein decreases in rat kidney samples with age, this decrease is attenuated with caloric restriction | Rattus norvegicus | - |
| 3.4.22.52 | kidney | - |
Mus musculus | - |
| 3.4.22.52 | kidney | - |
Homo sapiens | - |
| 3.4.22.52 | kidney | - |
Rattus norvegicus | - |
| 3.4.22.52 | liver | - |
Homo sapiens | - |
| 3.4.22.52 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.B30 | additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Homo sapiens | ? | - |
? | |
| 3.4.22.B30 | additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Rattus norvegicus | ? | - |
? | |
| 3.4.22.B30 | additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.52 | calpain 1 | - |
Mus musculus |
| 3.4.22.52 | calpain 1 | - |
Homo sapiens |
| 3.4.22.52 | calpain 1 | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.22.52 | Mus musculus | compared with 5-month-old mice, there is no change in calpain 1 in 16-month-old mice | additional information |
| 3.4.22.52 | Rattus norvegicus | there is no age-dependent change in calpain 1 protein expression in control or caloric-restricted rats. Liver samples taken from control rats at 4, 9, and 24 months and from caloric-restricted rats at 24 months do not exhibit any changes in calpain 1 protein expression | additional information |
| 3.4.22.52 | Homo sapiens | there is no age-related change in calpain 1 protein expression in human female or male kidney samples. In the human kidney, there is no age-related change in calpain 1 mRNA expression | additional information |
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